MASSIVELY PARALLEL REPORTER ASSAY CONFIRMS REGULATORY POTENTIAL OF HQTLS AND REVEALS IMPORTANT VARIANTS IN LUPUS AND OTHER AUTOIMMUNE DISEASES

Massively parallel reporter assay confirms regulatory potential of hQTLs and reveals important variants in lupus and other autoimmune diseases

Summary: We designed a massively parallel reporter assay (MPRA) in an Epstein-Barr virus transformed B cell line to directly characterize the potential for histone post-translational modifications, i.e., histone quantitative trait loci (hQTLs), expression QTLs (eQTLs), and variants on systemic lupus erythematosus (SLE) and autoimmune (AI) disease C

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Creating Affording Situations: Coaching through Animate Objects

We explore the ways in which animate objects can be used to cue actions as part of coaching in Activities of Daily Living (ADL).In this case, changing the appearance or behavior of a physical object is intended to cue actions which are appropriate for a Diabetes Monitoring - Glucose Meter Controls given context.The context is defined by the intenti

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